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He has variants in his SORL1 that also make him at risk for Alzheimer's according to 2007 data. He has variants in his APOE gene sequence that are associated with Alzheimer's and cardiovascular diseases. Venter has written about his genome sequence in A Life Decoded. Most of these were already known as variants in the human population but 31% were new variants (in 2007). When the two copies of all annotated genes were compared, it turned out that 44% were heterozygous-the two copies were not identical.Ĭraig Venter's genome sequence differs from the composite human reference genome at 4,118,889 positions. The two haploid genomes differ by about 0.5% by this calculation (total amount sequenced was 2,895Mb). The total number of nucleotide differences is 13.9Mb when you add up all the indels, SNPs, and duplications. In addition, there were 62 copy number variants (duplication) accounting for an additional 10Mb of variation between haploid sets of chromosomes. Thus, indels made up 74% of the total number of variant nucleotide sequence. The rest were indels (insertions and deletions) and these accounted for 0.9 million nucleotides. 78% of these events were single nucleotide polymorphisms (SNPs). There were 4.1 million differences between homologous chromosomes (22 autosomes). In other words, enough data was generated to put together separate sequences of each pair of chromosomes. What's unique about this genome sequence-other than the fact that it's God's Craig Venter's-is that all 46 chromosomes were sequenced. The paper was published in PLoS Biology (Levy et al., 2007) and highlighted in a Nature News article: All about Craig: the first 'full' genome sequence. It took another seven years to finish and publish the complete sequence of all of Craig Venter's chromosomes. It was mostly his genome, making him the second being to know his own instruction book.
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The second sequence was from Celera Genomics, led by Craig Venter. "It is humbling for me and awe-inspiring to realize that we have caught the first glimpse of our own instruction book, previously known only to God."The sequence was a composite of a number of individuals. One was the product of the International Human Genome Project led by Francis Collins who said, The sequence of the human genome was announced on Jalthough the actual sequence wasn't published until a year later.
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